Spondias purpurea is used in folk medicine to treat diarrhea and diuresis. The objective of this study was to evaluate\nthe phytochemical profile and antioxidant and antiulcer activities of the hexane extract of the leaves of S. purpurea\n(SpHE). Phytochemical profile was evaluated via thin layer chromatography (TLC) and HPLC. SpHE was screened for\nantioxidant activities using DPPH, ABTS, FRAP, and phosphomolybdenum assays. To determine its antiulcer properties,\nanimals were pretreated with injured control, lansoprazole, ranitidine, carbenoxolone, or SpHE (12.5, 25, and 50 mg/kg)\nand were screened; acute ulcers were induced by HCl/ethanol, absolute ethanol, and nonsteroidal anti-inflammatory drug\n(NSAID). TLC revealed the presence of flavonoids, whereas HPLC analysis showed the presence of caffeic acid and\nepigallocatechin. The phenolic compounds and in vitro assays showed antioxidant activity. After gastric ulcer induction\nby using HCl/ethanol, SpHE reduced the area of ulcerative lesions by 82, 91, and 88%, respectively. In ethanol, SpHE\nreduced the area of ulcerative lesions by 77, 93, and 92%, respectively. In the NSAID, the percentages of protection\nwere 70, 76, and 78%, respectively. SpHE promoted the minimization of ulcers, increased the levels of reduced\nglutathione, and decreased tumor necrosis factor. S. purpurea has antioxidant and antiulcer properties.
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